Atropa belladonna Overview Page

Permission granted to use by Dr. Cornelius Barry

Common Name

Deadly Nightshade; Belladonna

Taxonomic Classification

Solanaceae family

Drug Uses

Atropa belladonna is one of the most poisonous plants known, with all parts of the plant containing toxic tropane alkaloids. A. belladonna extracts have been used since ancient times as both a poison and as a cosmetic agent for dilation of the pupils. A number of the A. belladonna alkaloids are used in modern medicine as anticholinergic agents. Atropine is used for a wide variety of conditions, including bradychardia and Wenckebach block. Scopolamine (levo-duboisine, hyoscine) is used to treat motion sickness in the form of a patch. Hyoscyamine alleviates the symptoms of various gastrointestinal disorders. Donnatal combines A. belladonna alkaloids hyoscyamine, atropine and scopolamine with phenobarbital to treat intestinal cramping.

Chemical Structure: AtropineClinical TrialsMajor Metabolites

Enzyme Information

Enzyme NameEC NoGenbank AccessionGI No
Hyoscyamine 6 beta-hydroxylase1.14.11.11BAA78340.14996123

Entries in Genbank

dbEST/(Kb) dbGSS/(Kb) dbPLN/(Kb) dbHTG/(Kb) Total Entriesa/(Kb)

aThe Total Entries column is the sum of the entries from the dbEST, dbGSS, dbPLN, and dbHTG columns. Data retrieved from NCBI on May 14 2010.

Transcript Assemblies


    Cloned Genes

    • Arginine decarboxylase (ADC)
    • Agmatine iminohydrolase (AIH)
    • N-carmaboylputrescine amidohydrolase (CPA)
    • Putrescine-N-methyltransferase (PMT)
    • Hyoscyamine 6 beta-hydroxylase (H6H)

    Pubmed Records

    See all Atropa belladonna papers within last Week, Month or Year.