Atropa belladonna Overview Page
Permission granted to use by Dr. Cornelius Barry
Common NameDeadly Nightshade; Belladonna | Taxonomic ClassificationSolanaceae family |
Drug Uses
Atropa belladonna is one of the most poisonous plants known, with all parts of the plant containing toxic tropane alkaloids. A. belladonna extracts have been used since ancient times as both a poison and as a cosmetic agent for dilation of the pupils. A number of the A. belladonna alkaloids are used in modern medicine as anticholinergic agents. Atropine is used for a wide variety of conditions, including bradychardia and Wenckebach block. Scopolamine (levo-duboisine, hyoscine) is used to treat motion sickness in the form of a patch. Hyoscyamine alleviates the symptoms of various gastrointestinal disorders. Donnatal combines A. belladonna alkaloids hyoscyamine, atropine and scopolamine with phenobarbital to treat intestinal cramping.
| Chemical Structure: Atropine | Clinical Trials | Major Metabolites |
|---|---|---|
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Enzyme Information
| Enzyme Name | EC No | Genbank Accession | GI No |
|---|---|---|---|
| Putrescine-N-methyltransferase | 2.1.1.53 | BAA82264.1 | 5381174 |
| Putrescine-N-methyltransferase | 2.1.1.53 | BAA82262.1 | 5381170 |
| Putrescine-N-methyltransferase | 2.1.1.53 | BAA82261.1 | 5381168 |
| Hyoscyamine 6 beta-hydroxylase | 1.14.11.11 | BAA78340.1 | 4996123 |
Entries in Genbank
| dbEST/(Kb) | dbGSS/(Kb) | dbPLN/(Kb) | dbHTG/(Kb) | Total Entriesa/(Kb) |
|---|---|---|---|---|
| 0 (0kb) | 0 (0kb) | 66 (372.5kb) | 0 (0kb) | 66 (372.5kb) |
aThe Total Entries column is the sum of the entries from the dbEST, dbGSS, dbPLN, and dbHTG columns. Data retrieved from NCBI on May 14 2010.
Transcript Assemblies
Cloned Genes
- Arginine decarboxylase (ADC)
- Agmatine iminohydrolase (AIH)
- N-carmaboylputrescine amidohydrolase (CPA)
- Putrescine-N-methyltransferase (PMT)
- Hyoscyamine 6 beta-hydroxylase (H6H)
Pubmed Records
- 138 records
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